Evaluation of Visual Field and Perg Parameters of Glaucomatous Patients Under Oral Supplement By Forskolin, Magnesium, Homotaurin, L-Carnosin, Vitamins B1, B2, B6 And Folic Acid

Forskolin, magnesium, homotaurin, L-carnosin, vitamins B1, B2, B6 and folic acid are the main ingredients of a food supplement commercially available. This drug contributes to a small reduction of IOP in glaucomatous patients who are poorly responsive to multitherapy treatment. The aim of this study is to evaluate a possible change of visual field and pattern-electroretinogram (PERG) parameters after oral supplement of this drug. PATIENTS AND METHODS: This is a single center, retrospective study. It was conducted on files of 20 (10 M, 10 F) treated glaucomatous patients and 20 (10 M, 10 F) untreated controls. All these patients were affected by open-angle glaucoma under monotherapy but this association was supplemented twice a day to 20 patients as long as 12 months. The ophthalmological data (IOP, pachymetry, visual field assessment by FDT 30-2 strategy pattern standard deviation, PERG) were checked at time 0, 3 6, 9 and 12 months from the beginning of the oral therapy. The statistical analysis was performed by descriptive statistics, one-way ANOVA and Wilcoxon test. Results were considered significantly different when p<0.05. RESULTS: The two groups were age and sex-matched (p=0.335). The two groups were also matched as for pachymetry (p=0.187). The visual field parameter (mean deviation and pattern standard deviation by FDT 30-2 strategy) was statistically significantly different only at time 12 months (p=0.04). The PERG amplitude increases by 16.12%±2.6 at time 9 months and fovea sensitivity by 16.57%±3.2 at time 6 months (p<0.05). CONCLUSIONS: Our preliminary data stress the neuroprotective effect of the association of forskolin, magnesium, homotaurin, Lcarnosin, vitamins B1, B2, B6 and folic acid from a campimetric and electrophysiological point of view. .FINANCIAL DISCLOSURE: The Author has no financial disclosure in any drug used in this paper.